Should I Take Ubrelvy or Sumatriptan First?


Introducing the Two Medications

When it comes to treating migraine attacks, two commonly used medications are Ubrelvy and Sumatriptan. Ubrelvy is a newer medication specifically designed for acute migraine treatment, while Sumatriptan is a well-established and widely used medication for migraine relief. Both medications can be effective in alleviating symptoms, but the choice between them depends on various factors.

Considering the Factors

Several factors should be taken into account when deciding whether to take Ubrelvy or Sumatriptan as your first choice for migraine treatment.

Severity of the Migraine

The severity of your migraine attack can influence the choice of medication. If you are experiencing a severe migraine, Sumatriptan may be a better option as it tends to provide quicker relief. For example, if you have a severe migraine that is accompanied by intense throbbing pain and nausea, Sumatriptan can help alleviate these symptoms more rapidly. On the other hand, if your migraine is moderate or mild, Ubrelvy might be worth trying as it has been shown to effectively relieve pain and associated symptoms. It can be particularly helpful for migraines that are less severe but still interfere with daily activities.

Past Experience with the Medications

Considering your pastexperience with migraine medications is crucial when making a decision. If you have previously tried one of the medications and had positive results, it might be worth sticking with that option. For instance, if you have taken Sumatriptan in the past and found it to be effective with minimal side effects, it could be a suitable first choice for your migraine treatment. However, if you have not tried either medication before, it is advisable to discuss with your healthcare provider to determine a suitable starting point based on your medical history and preferences.

Learn more about whether to take Sumatriptan or Nurtec first.

Weighing the Potential Side Effects

It is essential to consider the potential side effects of each medication before making a decision. Sumatriptan is known to cause more side effects such as nausea, dizziness, and chest tightness. However, it is important to note that not everyone experiences these side effects, and they are generally temporary. On the other hand, Ubrelvy is generally well-tolerated, with some patients experiencing mild side effects like nausea or somnolence. If you are concerned about potential side effects, discussing them with your healthcare provider can help you make an informed decision. Your healthcare provider can also provide guidance on how to manage and minimize any side effects that you may experience.

Seeking Medical Advice

Ultimately, it is essential to consult with your healthcare provider before making a decision. They can assess your individual situation, medical history, and any other factors that may influence the choice of medication. They may also take into consideration any other medications you are currently taking to ensure there are no potential interactions. Your healthcare provider has the expertise to guide you in choosing the most suitable medication for your migraines based on your specific needs and medical history. They can provide personalized advice that takes into account your unique situation.

Keeping a Record of Your Experiences

Regardless of which medication you choose to try first, it can be helpful to keep a record of your experiences. By noting the specific symptoms you experience during an attack and how each medication affects them, you can provide valuable information to your healthcare provider. For example, keeping a migraine diary can help you track the frequency, duration, and intensity of your migraine attacks, as well as the efficacy of the medications you try. This record can assist in making an accurate diagnosis and developing a better-tailored treatment plan. It can also help your healthcare provider track your progress over time and make any necessary adjustments to your treatment plan.

Learn more about tracking migraines to measure well-being over time.

Adjusting the Treatment Plan

Based on your experiences and consultation with your healthcare provider, adjustments to your treatment plan may be necessary. Migraine treatment is not a one-size-fits-all approach, and it may require some trial and error to find the most effective medication for your migraines. You may need to switch between medications or try a combination of treatments to achieve the best results. Regular follow-ups with your healthcare provider will allow for ongoing evaluation and optimization of your migraine treatment. It is important to communicate any changes in your symptoms or medication response to your healthcare provider so that they can make informed decisions about your ongoing treatment plan.


  1. (n.d.). How do Ubrelvy and Imitrex (sumatriptan) compare? Retrieved October 12, 2023, from,are%20able%20to%20tolerate%20triptans.
  2. Chiang, C.C., & VanderPluym, J.H. (2021). Ubrogepant in the Acute Management of Migraine: A Narrative Review. Journal of Pain Research, 14, 1185–1192.
  3. Medical News Today. (n.d.). Ubrelvy vs. Imitrex: Differences, similarities, and which is better for you. Retrieved October 12, 2023, from

Frequently Asked Questions

1. Are Ubrelvy and Sumatriptan the only options for treating migraines?

No, there are other medications available for the treatment of migraines. Ubrelvy and Sumatriptan are just two common examples. Your healthcare provider can help determine the most appropriate medication for your specific condition.

2. Can I take Ubrelvy and Sumatriptan together?

The concurrent use of Ubrelvy and Sumatriptan is not recommended unless specifically instructed by your healthcare provider. Using multiple migraine medications without proper guidance can increase the risk of side effects and interactions.

3. How long does it take for Ubrelvy to start working?

Ubrelvy is known for its fast onset of action, with some patients experiencing relief within one hour of taking the medication. However, individual response times can vary, so it is important to discuss your expectations with your healthcare provider.

4. Can I use Sumatriptan for daily migraine prevention?

No, Sumatriptan is not intended for daily use as a preventive medication. It is specifically designed for acute migraine treatment and should be used as directed by your healthcare provider.

5. Can both Ubrelvy and Sumatriptan be used by pregnant or breastfeeding women?

The use of any medication during pregnancy or while breastfeeding should be discussed with a healthcare provider. They can weigh the potential risks and benefits and provide guidance based on your individual circumstances.

6. What should I do if I experience side effects from either Ubrelvy or Sumatriptan?

If you experience side effects from either medication, it is important to report them to your healthcare provider. They can assess the severity of the side effects and make any necessary adjustments to your treatment plan.

7. Can I take either Ubrelvy or Sumatriptan with other medications I am currently taking?

It is important to inform your healthcare provider about all medications you are currently taking, including over-the-counter medications and supplements. Some medications may interact with Ubrelvy or Sumatriptan, so your healthcare provider can evaluate potential interactions and make recommendations accordingly.

8. Are there any lifestyle changes that can complement the use of Ubrelvy or Sumatriptan?

Yes, lifestyle changes can play a role in managing migraines. Identifying and avoiding triggers, managing stress levels, practicing relaxation techniques, getting regular exercise, and maintaining a healthy sleep schedule can all help reduce the frequency and severity of migraines.

9. Can either Ubrelvy or Sumatriptan cure migraines?

Ubrelvy and Sumatriptan are not curative treatments for migraines. They are intended to provide relief from migraine symptoms and alleviate the pain associated with migraine attacks.

10. How long should I use either Ubrelvy or Sumatriptan before determining their effectiveness?

The effectiveness of Ubrelvy or Sumatriptan can vary between individuals. It is recommended to use these medications as directed by your healthcare provider and keep track of your experiences, including response times and symptom relief. Regular communication with your healthcare provider will help in assessing the effectiveness of the medication and making any necessary adjustments to your treatment plan.


The decision to take Ubrelvy or Sumatriptan first depends on several factors, including the severity of the migraine, past experiences, side effect profiles, and medical advice. Each medication has its own benefits and considerations, and what works well for one person may not work as effectively for another. By considering these factors and working closely with your healthcare provider, you can make an informed decision about which medication to try first for the treatment of your migraines. Remember that everyone’s migraines are unique, and finding the right treatment approach may involve some trial and error.

Jenny from Migraine Buddy

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