Qulipta Side Effects, Dosage and Reviews For Migraine


The harsh truth stands: There is currently no cure for migraine. But that doesn’t mean all hope is lost for us! Thankfully, preventive medication like QULIPTA can help us better manage migraine attacks. 

Also known as antogepant, QULIPTA is an oral medication developed to prevent migraine attacks. It is joined by a family of migraine medication classes, known as gepants. QULIPTA blocks calcitonin gene-related peptide (CGRP) receptors, hence preventing migraine attacks. While that is a mouthful, what exactly is CGRP?

CGRP is a protein in the brain that is involved in the transmission of pain and is released during the course of a migraine attack. When CGRP is released, it causes intense inflammation in the brain coverings or the meninges. While migraine pathophysiology is still undergoing research, CGRP is believed to be heavily associated with the pain of a migraine attack. 

At some point, QULIPTA was the first and only oral medication used for preventive migraine medication. Nurtec (or rimegepant), which was initially approved for the acute treatment of migraine attacks, was approved by the FDA for preventive use of episodic migraine attacks in 2021.

QULIPTA Side Effects

As with most medications, QULIPTA may have side effects too. Here are some common side effects we may experience:

  • Constipation
  • Nausea
  • Fatigue
  • Weight loss


In a study published by the New England Journal of Medicine, more than half of the migraine patients who took QULIPTA in varying doses found that their monthly migraine attacks were reduced by half.

Another randomized placebo-controlled phase 3 study found that antogepant was highly safe and effective. Also, the trial demonstrated that more than 50% participants in the groups receiving antogepant experienced 50% or more reduction in migraine days compared with 29% of participants in the placebo group who achieved this reduction.


The recommended dose is 10 mg, 30 mg, or 60 mg orally, once daily. However, that depends on what your medical care provider prescribe.

Should I take QULIPTA?

While there are many patients who experienced reduction in migraine days, it is still important to consult a doctor to evaluate the suitability of taking QULIPTA.

By having a consistent schedule with migraine tracking with Migraine Buddy, we can better track the patterns with migraine medication efficacy. It also serves as an objective record to show your doctors.

Download Migraine Buddy now!

Jenny from Migraine Buddy

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