Most frequent Migraine Comorbidities

Migraine Comorbidities
Migraine is not just a standalone neurological disorder; it often coexists with various other medical conditions, known as comorbidities. Understanding these comorbidities is essential for comprehensive migraine management and improving the quality of life for sufferers. Here are some key comorbid conditions frequently associated with migraine:

1. Mood Disorders

Depression and anxiety are significantly more prevalent in individuals with migraines compared to the general population. The bidirectional relationship suggests that the presence of one can increase the likelihood of the other, potentially due to shared pathophysiological mechanisms.

2. Epilepsy

There is a notable comorbidity between migraine and epilepsy. Both conditions share common pathophysiological pathways involving neuronal hyperexcitability. Managing one condition effectively can sometimes help in controlling the other.

3. Cardiovascular Diseases

Migraine sufferers, particularly those with aura, have an increased risk of cardiovascular diseases, including stroke and heart disease. This connection underscores the importance of cardiovascular risk assessment in patients with migraines.

4. Irritable Bowel Syndrome (IBS)

IBS is frequently reported among migraineurs. The gut-brain axis plays a crucial role in this comorbidity, suggesting that gastrointestinal health should be a consideration in migraine management

5. Other Neurological Conditions

Besides epilepsy, other neurological conditions like stroke and sub-clinical vascular brain lesions are also common among those with migraines, necessitating a thorough neurological evaluation for individuals experiencing chronic migraines.

The Importance of Recognizing Comorbidities

Recognizing and managing these comorbidities can lead to better overall treatment outcomes for migraine patients. It helps in tailoring more effective and individualized treatment plans, reducing the burden of multiple chronic conditions, and improving patient quality of life.


Migraine comorbidities are varied and can significantly impact the management and prognosis of the condition. Understanding these associations can facilitate better clinical practices and enhance the quality of life for individuals with migraines.

🌐 Sources

  1. – Life Migraine Comorbidities
  2. – Comorbid and co-occurring conditions in migraine and …
  3. – Migraine comorbidity
  4. – Migraine Comorbidities Library
  5. – Migraine: treatments, comorbidities, and quality of life, in …
  6. – Comorbidities of Migraine – PMC
Jenny from Migraine Buddy

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