Advances in Migraine Research: Promising New Treatments

Advances in Migraine Research: Promising New Treatments

Introduction to Migraine Treatment

Migraine attacks are debilitating episodes that can significantly impact a person’s quality of life. Finding effective treatments is crucial to alleviate symptoms and reduce the frequency of migraine attacks. Ongoing research plays a vital role in developing new and improved treatments for migraines.

Overview of Traditional Migraine Treatments

Triptans and their Effectiveness

Triptans are a commonly prescribed class of medications used for treating acute migraine attacks. They work by binding to serotonin receptors in the brain and narrowing blood vessels, reducing inflammation and relieving pain. Triptans provide quick relief from migraine symptoms, including headache pain, nausea, and sensitivity to light and sound.

For example, one type of triptan, sumatriptan, is available in oral, nasal spray, and injectable forms. It is known for its effectiveness in providing rapid relief from migraines.

However, triptans may have potential side effects such as dizziness, drowsiness, and tightness in the chest. It is important to discuss the use of triptans with a healthcare provider to determine if they are a suitable treatment option.

For a more detailed understanding of triptans, read our article on Triptans and Migraine Treatment.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat mild to moderate migraine attacks. They help reduce pain and inflammation associated with migraines. Examples of NSAIDs commonly used for migraines include ibuprofen, naproxen, and aspirin.

For example, research has shown that ibuprofen, when taken at the onset of a migraine attack, can effectively reduce the severity and duration of the attack.

However, NSAIDs have limitations and potential risks, including gastrointestinal side effects and interactions with other medications. It is important to consult with a healthcare provider before using NSAIDs for migraine treatment.

To learn more about NSAIDs and their effectiveness in migraine treatment, visit our article on NSAIDs for Migraine Treatment.

Preventive Medications

Preventive medications are prescribed to individuals who experience frequent or severe migraine attacks. They aim to reduce the frequency and intensity of migraines. Commonly prescribed preventive drugs include beta blockers, antidepressants, and anti-seizure medications.

For example, beta blockers such as propranolol are often prescribed to help prevent migraines by reducing the frequency and intensity of attacks. They work by blocking certain receptors in the heart and blood vessels, which can help regulate blood pressure and prevent migraines.

While preventive medications can be effective, they have drawbacks and limitations. Some individuals may experience side effects such as fatigue, weight gain, or mood changes. It is important to consult with a healthcare provider to determine if preventive medications are suitable for your specific case.

For a comprehensive guide on preventive medications, read our article on Preventive Medications for Migraine.

Introduction to Promising New Treatments

Ongoing research is exploring novel approaches to migraine treatment that show promise in providing relief for those who suffer from migraines.

Targeted Therapy: CGRP Inhibitors

CGRP (calcitonin gene-related peptide) plays a crucial role in migraine attacks by transmitting pain signals. CGRP inhibitors are a new class of medications that work by blocking CGRP to prevent migraines from occurring. These medications have shown significant success in reducing the frequency and severity of migraines.

One example of a CGRP inhibitor is Aimovig (erenumab), which is administered as a monthly injection. Aimovig has been shown to significantly reduce the number of migraine days experienced by individuals in clinical trials.

To learn more about CGRP inhibitors and their effectiveness, side effects, and cost considerations, read our article on CGRP Inhibitors for Migraine.

Lasmiditan: A New Type of Acute Migraine Treatment

Lasmiditan is a medication specifically designed for the acute treatment of migraines. It works differently than triptans, targeting serotonin receptors to alleviate headache pain and associated symptoms. Lasmiditan does not constrict blood vessels like triptans do.

One advantage of lasmiditan over triptans is that it does not cause vasoconstriction, making it a suitable option for individuals with cardiovascular conditions. It has also been shown to have longer-lasting relief compared to some triptans.

For example, lasmiditan has demonstrated effectiveness in relieving migraine pain within two hours for a significant number of individuals in clinical trials.

However, like any medication, lasmiditan has potential side effects, such as dizziness and fatigue. It is important to discuss with a healthcare provider to determine if lasmiditan is an appropriate treatment option for you.

Discover more about lasmiditan, its mechanism of action, and its potential benefits and side effects in our article on Lasmiditan for Migraine.

Neuromodulation Devices

Neuromodulation devices offer non-pharmacological treatment options for migraines. These devices use electrical or magnetic stimulation to modulate brain activity and reduce migraine symptoms.

Transcranial magnetic stimulation (TMS) is a non-invasive technique where magnetic pulses are applied to the scalp to stimulate specific regions of the brain associated with migraines. It has shown effectiveness in reducing the frequency and severity of migraines for some individuals.

For example, research studies have demonstrated that regular sessions of TMS can result in a significant decrease in migraine frequency and pain intensity.

Non-invasive vagus nerve stimulation (nVNS) is another option for migraine prevention. It involves the use of a handheld device that delivers mild electrical stimulation to the vagus nerve, which runs through the neck and is involved in migraines. nVNS has shown efficacy in reducing both the frequency and severity of migraines.

To learn more about these neuromodulation devices and how they work, read our article on Neuromodulation Devices for Migraine.

Exploring the Effectiveness of New Treatments

Clinical trials and research studies play an essential role in assessing the safety and efficacy of new migraine treatments. These studies involve participants who provide feedback on their experiences and the effects of the treatments.

When evaluating new treatments, it is important to consider their overall effectiveness in reducing migraine frequency and severity. However, individual patient factors, such as coexisting conditions and potential interactions with other medications, should also be taken into account.

The Importance of Patient-Doctor Communication

Tracking and Reporting Symptoms

Keeping a record of migraine symptoms is crucial for effective communication with healthcare providers. Maintaining a migraine diary that includes details such as the date and time of each attack, duration, intensity, associated symptoms, and potential triggers can provide valuable insights for accurate diagnosis and treatment planning.

For example, noting the specific location and quality of the headache, any aura or prodrome symptoms, and the impact on daily activities can help healthcare providers assess the severity of your migraines and tailor treatment plans.

To learn more about tracking symptoms and measuring treatment efficacy, visit our article on Tracking Migraine Symptoms.

Discussing Treatment Options and Concerns

Open and honest communication with healthcare providers is essential when discussing treatment options and expressing concerns. Patients should ask questions about the effectiveness of new treatments based on their individual migraine patterns and the potential side effects and interactions with other medications.

For example, you may want to inquire about the specific mechanism of action of a new treatment, how long it typically takes to see results, and any potential lifestyle adjustments that may be necessary.

For a comprehensive list of questions to ask your healthcare provider, read our article on Questions to Ask About New Migraine Treatments.


Advances in migraine research have provided promising new treatments for those who suffer from migraines. The development of CGRP inhibitors, lasmiditan, and neuromodulation devices offers additional options for managing migraines. Effective patient-doctor communication, tracking of symptoms, and shared decision-making play vital roles in tailoring treatment plans to meet individual needs.

Continue to stay informed about the latest advancements and collaborate with your healthcare provider to find the most suitable treatment approach for your migraines.

Jenny from Migraine Buddy

You Will Also Like

Back to Blog

Leave your mobile to get a link to download the app